Stanley Kubrick in his 1968 interview with Playboy:

The most terrifying fact of the universe is not that it is hostile but that it is indifferent; but if we can come to terms with this indifference and accept the challenges of life within the boundaries of death — however mutable man may be able to make them — our existence as a species can have genuine meaning and fulfillment.However vast the darkness, we must supply our own light.

via Daring Fireball.